BNC105P, the disodium phosphate ester of BNC105, is a potent benzofuran-based tubulin polymerization inhibitor and also a vascular disrupting agent (VDA) prodrug with potential anti-vascular and anticancer activities. BNC105P is rapidly converted to BNC105 under in vivo conditions. BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.

纯度：≥98%

CAS：945771-96-0