Guanfacine is a potent, selective and centrally acting alpha-2 adrenergic agonist with antihypertensive activity and with Kd of 31 nM. It displays 60-fold selectivity over α2B-adrenoceptors. Alpha-2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. This leads to a decrease in heart rate and peripheral vascular resistance.

纯度：≥98%

CAS：29110-47-2