Apricitabine [(-)-BCH-10652; (-)-dOTC; AVX-754; BCH-10618; SPD-754] is a highly potent, selective and orally bioactive HIV-1 reverse transcriptase (RT) inhibitor with Ki of 0.08 μM, belonging to the nucleoside reverse transcriptase inhibitor (NRTI) class of anti-HIV agents. It also inhibits DNA polymerases α, β, and γ with Ki value of 300 μM, 12 μM, and 112.25 μM, respectively. It is structurally related to lamivudine and emtricitabine, and, like these, is an analogue of cytidine.
纯度:≥98%
CAS:160707-69-7