(R)-Nepicastat HCl [RS-25560-198 HCl]
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
| CAS NO: | 195881-94-8 |
| 规格: | ≥98% |
包装与价格：
| 包装 | 价格(元) |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| 500mg | 询价 |
理化性质和储存条件
| Molecular Weight (MW) | 331.81 |
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| Formula | C14H15F2N3S.HCl |
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| CAS No. | 195881-94-8 |
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| Storage | -20℃ for 3 years in powder form |
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| -80℃ for 2 years in solvent |
| Solubility (In vitro) | DMSO: 66 mg/mL (198.9 mM) |
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| Water: <1 mg/mL |
| Ethanol: <1 mg/mL |
| Solubility (In vivo) | 30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
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| Synonyms | RS-25560-198 HCl; RS-25560 198 HCl; RS 25560-198 HCl; RS25560-198 HCl |
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| SMILES Code | S=C1N([C@H]2CC3=C(C(F)=CC(F)=C3)CC2)C(CN)=CN1.[H]Cl |
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实验参考方法
| In Vitro | In vitro activity: (R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro. |
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| In Vivo | (R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs). |
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| Animal model | Animal Models Spontaneously hypertensive rats (SHRs). |
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| Formulation & Dosage | Dissolved in distilled water; 30 mg/kg; p.o. |
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| References | Br J Pharmacol. 1997 Aug;121(8):1803-9. |
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![(R)-Nepicastat HCl [RS-25560-198 HCl]图片](http://www.cnprot.com/data/daily/2023/02/05/233337_265867_umcs_1047908.png)