| CAS NO: | 1452-77-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1g | 询价 |
| 2g | 询价 |
| 5g | 询价 |
| 10g | 询价 |
| 25g | 询价 |
| 100g | 询价 |
| Molecular Weight (MW) | 122.12 |
|---|---|
| Formula | C6H6N2O |
| CAS No. | 1452-77-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 24 mg/mL (196.5 mM) |
| Water: 24 mg/mL (196.5 mM) | |
| Ethanol: 24 mg/mL (196.5 mM) | |
| Other info | SMILES: NC(=O)c1ccccn1 InChI: 1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9) InChI key: IBBMAWULFFBRKK-UHFFFAOYSA-N |
| Synonyms | 2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine |
| In Vitro | In vitro activity: Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment. Cell Assay: The pathway of oxidation of picolinamide by a Gram-negative rod has been elucidated. Results showed that under high pH conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. Moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. In addition, whole cells were found to oxidize picolinamide, without lag. It was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate. |
|---|---|
| In Vivo | Picolinamide was used in a previous study to evaluate the possibility that the inhibition of Na+/phosphate cotransport might be associated with the inhibition of NAD hydrolyzing enzymes. Results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit Na+/phosphate cotransport by isolated renal brush border membrane vesicles. Similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for Na+/phosphate cotransport. Unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical NAD content after picolinamide treatment. |
| Animal model | Wistar rats |
| Formulation & Dosage | Dissolved in 0.9% NaCl solution; 250 mg/kg; i.p. injection |
| References | Cancer Res. 1985 Apr;45(4):1845-9; J Biol Chem. 1982 Jun 10;257(11):6084-8; J Pharmacol Exp Ther. 1989 Oct;251(1):188-92. |
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