TP-434(1334714-66-7,Eravacycline dihydrochloride)是一种新型氟环素，TP-434对革兰氏阳性和革兰氏阴性需氧和厌氧性病原体均具有广谱活性，包括重要的耐药菌，如耐甲氧西林的金黄色葡萄球菌（MRSA），万古霉素耐药肠球菌（VRE）和产广谱β-内酰胺酶（ESBL）和产碳青霉烯酶的肠杆菌科细菌和多药耐药鲍曼不动杆菌等。
| 中文别名 | TP-434(cas:1334714-66-7),TP-434 dihydrochloride,TP-434-046 |
| 英文别名 | Eravacycline dihydrochloride;1334714-66-7;TP-434;Eravacycline dihydrochloride;(4S,4aS,5aR,12aS)-4-(Dimethylamino)-7-fluor-3,10,12,12a-tetrahydroxy-1,11-dioxo-9-[(1-pyrrolidinylacetyl)amino]-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracencarboxamiddihydrochlorid |
| CAS号 | 1334714-66-7 |
| SMILES | O=C(NC(C(O)=C1C2=O)=CC(F)=C1C[C@@]3([H])C[C@@]4([H])[C@H](N(C)C)C(O)=C(C(N)=O)C([C@@]4(O)C(O)=C32)=O)CN5CCCC5.[H]Cl.[H]Cl |
| Inchi | InChI=1S/C27H31FN4O8.2ClH/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39;;/h9,11,13,20,34,36-37,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33);2*1H/t11-,13-,20-,27-;;/m0../s1 |
| InchiKey | JYCNMRVZELJVAW-RZVFYPHASA-N |
| 分子式 Formula | C27H33Cl2FN4O8 |
| 分子量 Molecular Weight | 631.48 |
| 溶解度Solubility | 生物体外In Vitro:H2O : 50 mg/mL(79.18 mM;Need ultrasonic) |
| 性状 | Solid |
| 储藏条件 Storage conditions | 4℃, stored under nitrogen * In solvent : -80℃, 6 months月; -20℃, 1 month月 (stored under nitrogen) |
