| CAS NO: | 144217-65-2 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| 500mg | 询价 |
| Molecular Weight (MW) | 317.43 |
|---|---|
| Formula | C18H27N3O2 |
| CAS No. | 144217-65-2 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO:<1 mg/mL |
| Water:<1 mg/mL | |
| Ethanol:<1 mg/mL | |
| Solubility (In vivo) | O=C(NC1CC(C)(C)NC(C)(C)C1)C(NC2=CC=C(C)C=C2)=O |
| Synonyms | YYA-021; YYA 021; YYA021 |
| In Vitro | In vitro activity: YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodeficiency virus type 1 (HIV-1) isolate MNA. Kinase Assay: YYA-021 is a small-molecule CD4 mimic that inhibits HIV entry, with high anti-HIV activity and low cytotoxicity. IC50 value: 8.4 μM Cell Assay: HIV IC50 (=8.4 μM) value of YYA-021 is determined by a single round assay using cYTA48P virus and TZM-bl cells. YYA-021 is broadly distributed in tissues, probably as a result of its hydrophobicity. The plasma concentrations of YYA-021 in both species remained at micromolar levels for several hours post-injection. |
|---|---|
| In Vivo | Rats and rhesus macaques |
| Animal model | Rat, dog and monkey |
| Formulation & Dosage | 14 mg/kg (rats), 13.4 mg/kg (rhesus macaques); i.v. injection |
| References | J Gen Virol. 2013 Dec;94(Pt 12):2710-6; Bioorg Med Chem. 2013 Dec 15;21(24):7884-9. |
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