VPS34-IN1 (VPS34-IN-1) is a novel and potent Vps34 (vacuolar protein sorting 34) inhibitor with potential
antitumor activity. It inhibits Vps34 with an 25 nM IC50 and exhibits no activity against 350 closely related protein kinases
or lipid kinases. The Vps34 class III PI3K (phosphoinositide
3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal
membranes to generate PtdIns(3)P that regulates membrane trafficking
processes via its ability to recruit a subset of proteins possessing
PtdIns(3)P-binding PX (phox homology) and FYVE domains.
纯度:≥98%
CAS:1383716-33-3