Sulforaphane (BroccoPhane; Detoxophane) is a naturally-occurring isothiocyanate widely found in consumed vegetables. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. Sulforaphane activates Nrf2 and inhibits high glucose-induced
progression of pancreatic cancer via AMPK dependent signaling.
Sulforaphane has shown anti-cancer and anti-inflammatory activities.