| CAS NO: | 1986-47-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 询价 |
| 250mg | 询价 |
| 500mg | 询价 |
| 1g | 询价 |
| 2g | 询价 |
| Molecular Weight (MW) | 169.65 |
|---|---|
| Formula | C9H12ClN |
| CAS No. | 1986-47-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 33 mg/mL (194.5 mM) |
| Water: N/A | |
| Ethanol: 33 mg/mL (194.5 mM) | |
| Other info | Chemical Name: trans-2-Phenylcyclopropylamine Hydrochloride InChi Key: ZPEFMSTTZXJOTM-OULXEKPRSA-N InChi Code: InChI=1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1 SMILES Code: N[C@H]1[C@H](C2=CC=CC=C2)C1.[H]Cl |
| Synonyms | SKF-385 HCl; SKF 385 HCl; 2-PCPA Hydrochloride; SKF385 HCl; 2-PCPA HCl; Tranylcypromine hydochloride; Tranylcypromine HCl |
| In Vitro | In vitro activity: R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(–)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes. |
|---|---|
| In Vivo | Tranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats. |
| Animal model | Rats |
| Formulation & Dosage | 5 mg/kg and 10 mg/kg |
| References | Drug Metab Dispos. 2001 Jun;29(6):897-902; Environ Health Perspect. 2004 Aug;112(11):1159-64. |
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