| CAS NO: | 69-09-0 |
| 包装: | 100mg, 500mg |
Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 uM for nward-rectifying K+ currents and time-independent outward currents. The turnover of dopamine in the brain is also increased. Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect.
*该产品在溶液状态不稳定，建议您现配现用。
| 分子量 | 355.33 |
| 分子式 | C17H19ClN2S.HCl |
| CAS号 | 69-09-0 |
| 纯度 | 99.86% |
| 溶解性（25°C） | DMSO ≥ 60 mg/mL Water ≥ 60 mg/mL |
| 储存和运输条件 | -20°C, protect from light, dry, sealed 常温运输及临时存放 |
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8143 mL | 14.0714 mL | 28.1429 mL |
| 5 mM | 0.5629 mL | 2.8143 mL | 5.6286 mL |
| 10 mM | 0.2814 mL | 1.4071 mL | 2.8143 mL |
| 维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024 |