生物活性
Antiviral [herpes simplex virus (HSV) and human immunodeficiency virus (HIV)], antibacterial, superoxide radical-scavenging, and complement-modulating properties were assessed. In general, more pronounced activities were seen with epicatechin-containing dimers for anti-HSV, anti-HIV, and radical-scavenging effects, while the presence of ortho-trihydroxyl groups in the B-ring was important in compounds exhibiting anti-HSV and radical-scavenging effects and complement classical pathway inhibition.
化学数据
| 分子量 | 578.52 |
| 分子式 | C30H26O12 |
| CAS号 | 29106-51-2 |
| 纯度 | >98% |
| 溶解性（25°C） | DMSO |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存
常温运输及临时存放 |
实验操作 来自于公开的文献，仅供相同实验参考（如实验材料、目的不同，请参考其他文献）
| 细胞实验 |
|---|
| 细胞系 | RAW 264.7 cells |
| 方法 | At 80-90% confluency, the medium was replaced with a colorless DMEM medium with antibiotics and without FBS, and then the cells were stimulated with LPS and coincubated with procyanidins and PUFAs with a final concentration for the following compounds: B1, B2, B3, and B4 (5 mg/mL or 8.64 μM), and DHA and EPA (30 μM). After 19 h of treatment, the supernatant was collected and stored at -20℃. |
| 浓度 | 8.64 μM |
| 处理时间 | 19 h |
| 动物实验 |
|---|
| 动物模型 | male castrated pigs |
| 配制 | water |
| 剂量 | 10 mg/kg |
| 给药处理 | oral |
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
储备液配制
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7285 mL | 8.6427 mL | 17.2855 mL |
| 5 mM | 0.3457 mL | 1.7285 mL | 3.4571 mL |
| 10 mM | 0.1729 mL | 0.8643 mL | 1.7285 mL |
