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Blasticidin S HCl
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Blasticidin S HCl图片
CAS NO:3513-03-9
规格:≥98%
包装与价格：
包装价格(元)
50mg询价
100mg询价
250mg询价
500mg询价
1g询价

理化性质和储存条件
Molecular Weight (MW)458.9
FormulaC17H27ClN8O5
CAS No.3513-03-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: 91 mg/mL (198.3 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: (2S,3S,6R)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-((R)-3-amino-5-(1-methylguanidino)pentanamido)-3,6-dihydro-2H-pyran-2-carboxylic acid hydrochloride

InChi Key: YQXYQOXRCNEATG-ZAYJLJTISA-N

InChi Code: InChI=1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1

SMILES Code: O=C([C@@H]1[C@@H](NC(C[C@H](N)CCN(C(N)=N)C)=O)C=C[C@H](N2C=CC(N)=NC2=O)O1)O.[H]Cl

Synonyms

Blasticidin S HCl

实验参考方法
In Vitro

In vitro activity: Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA. Blasticidin S also significantly inhibits DNA synthesis independent of their effect on protein synthesis. Blasticidin S kills the cells more rapidly than G418, which makes blasticidin S-resistance gene (bsr) a selectable marker for mammalian cells. Besides, Blasticidin S also efficiently binds Cu(II) ions and prevents DNA from metal-induced damage.

In Vivo
Animal model
Formulation & Dosage
References

J Biochem. 1966 Dec;60(6):632-42; Biochim Biophys Acta. 1977 Mar 2;475(1):14-22.

 
 
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