PF-04859989 is a selective,
irreversible/co-valent and BBB-penetrant inhibitor of kynurenine amino
transferase II (KAT II) with a potential to be used for the treatment of
cognitive impairment associated with schizophrenia and other psychiatric
disorders. It is cyclic hydroxamic acid identified from a
high-throughput screen. PF04859989 acts by forming a covalent adduct
with the enzyme cofactor,
pyridoxal phosphate (PLP), in the active site. PF-04859989 is capable of
reducing brain kynurenic acid
by 50% at a dose of 10 mg/kg (sc).
纯度：≥98%
CAS：34783-48-7
