Sparstolonin B (SsnB) is a naturally occurring TLR2 and TLR4 antagonist isolated from the Chinese herb called Scirpus yagara. It blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activity. SsnB inhibited the expression of various inflammatory mediators such as tumor necrosis factor (TNF-α), interleukin (IL)-1β, IL-6, and chemokine (C-C motif) ligand 2 (CCL-2) in lipopolysaccharide (LPS)- or Pam3csk4-stimulated macrophages.

纯度：≥98%

CAS：1259330-61-4