| CAS NO: | 519-02-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| 500mg | 询价 |
| 1g | 询价 |
| Molecular Weight (MW) | 248.36 |
|---|---|
| Formula | C15H24N2O |
| CAS No. | 519-02-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 49 mg/mL (197.3 mM) |
| Water: 11 mg/mL (44.29 mM) | |
| Ethanol: 49 mg/mL (197.3 mM) | |
| Solubility (In vivo) | Chemical Name:
(41S,7aS,13aR,13bR)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one InChi Key: ZSBXGIUJOOQZMP-JLNYLFASSA-N InChi Code: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 SMILES Code: O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@H]([C@@H]34)CN12 |
| Synonyms | Vegard; α-Matrine; Matridin-15-one; NSC 146051; NSC146051; Matrine; NSC-146051; |
| In Vitro | In vitro activity: Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice. |
|---|---|
| In Vivo | Oral administration of matrine (200, 100 and 50 mg/kg) significantly attenuated isoproterenol-induced cardiac necrosis and left ventricular dysfunction. high dose of matrine significantly reduced the mortality rate of mice with LPS administration. Treatment with matrine improved LPS-induced lung histopathologic changes, alleviated pulmonary edema and lung vascular leak, inhibited MPO and MDA activity,and reduced the production of inflammatory mediators including TNF-α, IL-6 and HMGB1 |
| Animal model | Mouse |
| Formulation & Dosage | 200, 100 and 50 mg/kg |
| References | Biol Pharm Bull. 2005 May;28(5):845-8; Cytotechnology. 2009 Apr;59(3):191-200. |
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