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API-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
API-1图片
CAS NO:36707-00-3
规格:≥98%
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API-1 (API1) is a novel and potent Akt inhibitor, inducing GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis. It efficiently reduces the phosphorylation levels of Akt with an IC50 of ~0.8 μM. API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1. API-1 treatment decreased the half-life of Mcl-1, whereas inhibition of the proteasome with MG132 rescued Mcl-1 reduction induced by API-1. API-1 decreased Mcl-1 levels accompanied with a rapid increase in Mcl-1 phosphorylation (S159/T163). Moreover, inhibition of GSK3 inhibited Mcl-1 phosphorylation and reduction induced by API-1 and antagonized the effect of API-1 on induction of apoptosis.

纯度:≥98%

CAS:36707-00-3

 
 
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