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Tolazoline HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tolazoline HCl图片
CAS NO:59-97-2
规格:≥98%
包装与价格:
包装价格(元)
5mg询价
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100mg询价
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1g询价
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理化性质和储存条件
Molecular Weight (MW)196.68
FormulaC10H12N2.HCl
CAS No.59-97-2 (HCl salt);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 39 mg/mL (198.3 mM)
Water: 39 mg/mL (198.3 mM)
Ethanol: N/A
Other infoIUPAC/Chemical Name: 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, hydrochloride (1:1)
InChi Key: RHTNTTODYGNRSP-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H
SMILES Code: [H]Cl.C1(CC2=CC=CC=C2)=NCCN1
SynonymsTolazoline, Benzalolin, Divascol, Pridazole, Priscol, Priscoline
实验参考方法
In Vitro

In vitro activity: Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN). Tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance. Tolazoline is not as broadly effective as SNP against all spasmogens investigated. However, it may be effective in counteracting alpha-adrenoceptor-mediated vasospasm in human radial arteries.

In Vivo N/A
Animal model N/A
Formulation & Dosage N/A
ReferencesJ Cardiovasc Pharmacol. 1998 May;31(5):721-33; Ann Thorac Surg. 2006 Jan;81(1):125-31.
 
 
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