Description: NMS-P715 (NMSP715) is a selective and orally bioactive MPS1 inhibitor with antitumor activity. It selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumorally bioavailable cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer cells.

References: Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor, NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.

纯度：≥98%

CAS：1202055-34-2