Niclofolan is a biphenyl anthelmintic compound. Niclofolan is used orally towards the treatment of Fasciola hepatica infection. Niclofolan therapy achieved elimination of eggs from the feces and normalization of eosinophil counts, liver enzymes and Fasciola titers, suggesting eradication of biliary flukes. References: Ali BH, el Sheikh HA, McKellar QA. Pharmacokinetics of niclofolan in desert sheep. J Vet Pharmacol Ther. 1990 Jun;13(2):217-9. PubMed PMID: 2384912. 2: Ali BH, Hassan T, Haroun EM, Abu Samra MT. The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. J Vet Pharmacol Ther. 1985 Dec;8(4):398-403. PubMed PMID: 4094030. 3: Güralp N, Tinar R. Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. gigantica in sheep. J Helminthol. 1984 Jun;58(2):113-6. PubMed PMID: 6747253. 4: González H, Plaza J, Montes G, Pérez R, Toro P. [Anthelmintic activity of niclofolan and closantel against Fasciola hepatica in sheep]. Bol Chil Parasitol. 1983 Jul-Dec;38(3-4):42-9. Spanish. PubMed PMID: 6375690. 5: Reshef R, Lok AS, Sherlock S. Cholestatic jaundice in fascioliasis treated with niclofolan. Br Med J (Clin Res Ed). 1982 Oct 30;285(6350):1243-4. PubMed PMID: 6812826; PubMed Central PMCID: PMC1499778. 6: Hong ST, Lee SH, Ahn HS, Yun CK. A Case Of Niclofolan (Bilevon(R)) Intoxication. Kisaengchunghak Chapchi. 1982 Jun;20(1):49-52. PubMed PMID: 12902700. 7: Eckhardt T, Heckers H. Treatment of human fascioliasis with niclofolan. Gastroenterology. 1981 Oct;81(4):795-8. PubMed PMID: 7262525. 8: Ripert C, Carrie J, Ambroise-Thomas P, Baecher R, Kum NP, Same-Ekobo A. [Epidemiologic and clinical study of paragonimosis in Cameroon. Results of niclofolan treatment]. Bull Soc Pathol Exot Filiales. 1981 May-Jun;74(3):319-31. French. PubMed PMID: 7285268. 9: Bunnag D, Harinasuta T, Desakorn V. Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. Southeast Asian J Trop Med Public Health. 1981 Mar;12(1):107-9. PubMed PMID: 7020093. 10: Cao WJ. [Preliminary observation on the treatment of paragonimiasis westermani (thoracic type) with domestic niclofolan in 26 cases (author's transl)]. Zhonghua Nei Ke Za Zhi. 1980 May;19(3):226-9. Chinese. PubMed PMID: 7227061. 1 Ambroise-Thomas P, Wegner DH, Goullier A, Desgeorges PT, Billiault X. [Clinical trial of niclofolan (Bay 9015) in the treatment of human opisthorchiasis. Apropos of 51 cases]. Bull Soc Pathol Exot Filiales. 1980 May-Jun;73(3):293-301. French. PubMed PMID: 7014011. 12: Rim HJ, Kim MS, Ha JH, Chang DS. Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis. Kisaengchunghak Chapchi. 1976 Dec;14(2):140-146. PubMed PMID: 12913443. 13: Ueno H, Morales GL. Fasciolicidal activity of diamphenethide and niclofolan against Fasciola hepatica in sheep in the Altiplano region of Bolivia. Natl Inst Anim Health Q (Tokyo). 1973 Summer;13(2):75-9. PubMed PMID: 4792403. 14: Ueno H, Alvarez JM, De Mergen AM, Cabral AF, Bodden HA. Field trials with rafoxanide, bithionol sulfoxide and niclofolan against Fasciola hepatica in cattle in the dominican republic. Natl Inst Anim Health Q (Tokyo). 1973 Summer;13(2):69-74. PubMed PMID: 4792402.

纯度：≥98%

CAS：10331-57-4