BMY-25271是一个组胺H2受体(histamineH2receptor)拮抗剂。
CAS：78441-82-4
分子式：C12H19N5O2S2
分子量：329.44
纯度：98%
存储：Store at -20°C

Background:

BMY-25271 is a histamine H2 receptor antagonist.

BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED50 values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid[1].

[1]. Cavanagh RL, et al. Prevention of aspirin-induced gastric mucosal injury by histamine H2 receptor antagonists: a crossover endoscopic and intragastric pH study in the dog. J Pharmacol Exp Ther. 1987 Dec;243(3):1179-84.