C25-140是一种一流的TRAF6-Ubc13相互作用的抑制剂，直接与TRAF6结合，阻断TRAF6和Ubc13的相互作用，从而降低TRAF6活性并对抗自身免疫。
CAS：1358099-18-9
分子式：C26H31N7O
分子量：457.57
纯度：98%
存储：Store at -20°C

Background:

C25-140, a first-in-class TRAF6-Ubc13 inhibitor, directly binds to TRAF6, thereby blocks the interaction of TRAF6 with Ubc13 and as a consequence lowers TRAF6 activity and combats autoimmunity[1]. TRAF6-Ubc13[1]

C25-140 dose-dependently impedes TRAF6-Ubc13 interaction[1].C25-140 (10-30 μM; 2 hours) effectively reduces TRAF6-mediated ubiquitin chain formation[1].C25-140 affects TNFα-induced phosphorylation of IκBα as well as NF-κB-induced target gene expression[1].C25-140 efficiently inhibits IL-1β- and TNFα-mediated receptor signaling in the context of cytokine activation[1]. Western Blot Analysis[1] Cell Line: TRAF6WT

C25-140 (