位置:首页 > 产品库 > gamma-Secretase Modulators
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
gamma-Secretase Modulators
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
gamma-Secretase Modulators图片
CAS NO:937812-80-1
规格:98%
分子量:483.48

gamma-Secretase Modulators (Amyloid-β production inhibitor)是淀粉状蛋白β生成抑制剂,可作用于阿尔茨海默病。
CAS:937812-80-1
分子式:C26H24F3N3O3
分子量:483.48
纯度:98%
存储:Store at -20°C

Background:

gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer’s disease.IC50 value:Target: γ-secretase modulator




[1]. Watahiki H, Yagishita S, Futai E, Ishiura S.CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.Neurosci Lett. 2012 Sep 27;526(2):96-9. Epub 2012 Aug 23. [2]. Wanngren J, Ottervald J, Parpal S, Portelius E, Str•mberg K, Borgeg•rd T, Klintenberg R, JurÉus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlstr•m H.Second generation γ-secretase modulators exhibit different modulation of Notch β [3]. Wagner SL, Tanzi RE, Mobley WC, Galasko D.Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease.Arch Neurol. 2012 Jul 16:1-4. [4]. Bulic B, Ness J, Hahn S, Rennhack A, Jumpertz T, Weggen S.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer’s Disease.Curr Neuropharmacol. 2011 Dec;9(4):598-622. [5]. Kretner, Benedikt; Fukumori, Akio; Gutsmiedl, Amelie; Page, Richard M.; Luebbers, Thomas; Galley, Guido; Baumann, Karlheinz; Haass, Christian; Steiner, Harald. Attenuated A.beta.42 Responses to Low Potency .gamma.-Secretase Modulators Can Be Overcome for


 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024