Cbz-B3A是mTORC1转导的有效选择性抑制剂，与泛素1、2、4结合，Cbz-B3A还能抑制eIF4E结合蛋白的磷酸化。
CAS：1884710-81-9
分子式：C35H58N6O9
分子量：706.87
纯度：98%
存储：Store at -20°C

Background:

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

Cbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins. Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC50 of