Oteseconazole (VT-1161) 是一种有效、可口服的抗真菌剂，有效结合并抑制白色念球菌的 CYP51 (Kd，<39 nm)，但对人 cyp51 无明显作用。
CAS：1340593-59-0
分子式：C23H16F7N5O2
分子量：527.39
纯度：98%
存储：Store at -20°C

Background:

Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd,<39 nM), shows no obvious effect on human CYP51[1][2].

[1]. Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. [2]. Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.