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Mechlorethamine HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mechlorethamine HCl图片
CAS NO:55-86-7
包装:50mg
规格:98%
市场价:579元
分子量:192.51

DNA synthesis inhibitor
CAS:55-86-7
分子式:C5H11Cl2N.HCl
分子量:192.51
纯度:98%
存储:Store at -20°C

Background:

Chlormethine hydrochloride is a vesicant and necrotizing irritant destructive to mucous membranes. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. Target: Chlormethine is a nitrogen mustard . It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication. It binds to the N7 nitrogen on the DNA base guanine.


参考文献:
[1]. Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577.


 
 
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