ROCK inhibitor-2 是一种选择性 ROCK1 和 ROCK2 双抑制剂,IC50 值分别为 17 nM 和2 nM。
CAS:1127308-52-4
分子式:C21H20N2O2
分子量:332.4
纯度:98%
存储:Store at -20°C
Background:
ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively[1].
ROCK1|17 nM (IC50)|ROCK2|2 nM (IC50)
[1]. Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based DrugDesign. J Med Chem. 2018 Dec 27;61(24):11074-11100.