UDM-001651 是一种有效选择性的、口服生物可利用的蛋白酶激活受体 4 (PAR4) 拮抗剂 (IC50=4 nM；Kd=1.4 nM)。UDM-001651 在 γ-凝血酶诱导的富含血小板的血浆聚集测定 (γ-Thr PRP) 中显示抗血小板活性 (IC50=25 nM)。
CAS：1477497-01-0
分子式：C28H23N3O5S
分子量：513.56
纯度：98%
存储：Store at -20°C

Background:

UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP)[1]. IC50: 4 nM (PAR4)[1]Kd: 1.4 nM (PAR4)[1]

[1]. Miller MM, et al. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27.