| CAS NO: | 208538-73-2 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| 500mg | 询价 |
| Molecular Weight (MW) | 1292.26 |
|---|---|
| Formula | C56H70N9NaO23S |
| CAS No. | 208538-73-2 (Micafungin Sodium); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (77.4 mM) |
| Water: 100 mg/mL (77.4 mM) | |
| Ethanol: <1 mg/mL | |
| SMILES | O=S(OC1=CC([C@H](O)[C@@H](O)C(NC(C2N(C(C(NC([C@]([H])(C[C@@H](O)[C@@H](O)NC(C3N(C(C([C@H](O)CC(N)=O)N4)=O)C[C@H](C)[C@@H]3O)=O)NC(C5=CC=C(C6=NOC(C7=CC=C(OCCCCC)C=C7)=C6)C=C5)=O)=O)[C@H](O)C)=O)C[C@H](O)C2)=O)C4=O)=CC=C1O)([O-])=O.[Na+] |
| Synonyms | FK463 Sodium; FK 463 Sodium; FK-463 Sodium; Mycamine; FK-463 |
| In Vitro | In vitro activity: Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively). Fungus experiment: Micafungin decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively). |
|---|---|
| In Vivo | In a mouse model of septic A. fumigatus infection, micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When micafungin (0.1 mg/kg) combination with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. While non-treated mice survived for only 6 days. |
| Animal model | A mouse model with septic Aspergillus fumigatus (A. fumigatus) infection |
| Formulation & Dosage | 0.1, 0.32 and 1 mg/kg; s.c.; q.d. |
| References | Biofouling. 2013 Sep;29(8):909-15; J Antibiot (Tokyo). 2013 Aug;66(8):479-84. |
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