位置:首页 > 产品库 > Atomoxetine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Atomoxetine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atomoxetine图片
CAS NO:83015-26-3
规格:98%
分子量:255.4
包装与价格:
包装价格(元)
5mg询价
10mg询价
25mg询价
50mg询价

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively.
CAS:83015-26-3
分子式:C17H21NO
分子量:255.4
纯度:98%
存储:Store at -20°C

Background:

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively. It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides. In the rat prefrontal cortex (PFC), it increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner. It also has neuroprotective effects when administered prior to ischemic damage in a gerbil model of transient cerebral ischemia. Formulations containing atomoxetine have been used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.


 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2025