生物活性
Icariin对抑制PDE5A1、PDE5A2和PDE5A3的所有三种PDE5A亚型均有抑制作用，IC50值分别为1.0、0.75和1.1 μM。
靶点信息
化学数据
| 目录号 | A10464 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 676.7 |
| Formula | C33H40O15 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 489-32-7 |
| SMILES | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O |
溶解度
| In vitro | DMSO | 46 mg/mL (67.98 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 14.78 mL | 73.89 mL | 147.78 mL |
| 0.5 mM | 2.96 mL | 14.78 mL | 29.56 mL |
| 1 mM | 1.48 mL | 7.39 mL | 14.78 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.96 mL |
*The above data is based on the productmolecular weight 676.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
