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LDE225(NVP-LDE225,Sonidegib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LDE225(NVP-LDE225,Sonidegib)图片
CAS NO:956697-53-3
包装与价格:
包装价格(元)
5mg询价
10mg询价
50mg询价
100mg询价
10mM * 1mL in DMSO询价

LDE-225

生物活性

LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂,通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。

靶点信息

Smo (mouse) (Cell-free assay)Smo (human) (Cell-free assay)
1.3 nM2.5 nM

化学数据

目录号A10520
作用机制Antagonist (拮抗剂)
M. Wt485.5
FormulaC26H26F3N3O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.956697-53-3
SynonymsLDE-225
SMILESC[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F

溶解度

In vitro (25°C)DMSO82 mg/mL (168.89 mM)
WaterInsoluble
EthanolWarmed: 82 mg/mL (168.89 mM)
In vivo2% DMSO+corn oil9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.6 mL102.99 mL205.97 mL
0.5 mM4.12 mL20.6 mL41.19 mL
1 mM2.06 mL10.3 mL20.6 mL
5 mM0.41 mL2.06 mL4.12 mL

*The above data is based on the productmolecular weight 485.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

 
 
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