FIN56是一种特异性的铁死亡诱导剂。
CAS：1083162-61-1
分子式：C25H31N3O5S2
分子量：517.66
纯度：98%
存储：Store at -20°C

Background:

FIN56 is a specific inducer of ferroptosis.

FIN56 causes the loss of GPX4 activity in cell lysates. FIN56-induced cell death is suppressed by GFP-GPX4 fusion protein overexpression. FIN56 triggers ferroptosis through a mechanism involving the regulation of GPX4 protein abundance[1].

[1]. Shimada K, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.