生物活性
Paclitaxel (Taxol)是一种有丝分裂抑制剂，可稳定微管，从而干扰细胞分裂过程中微管的正常分解，在人内皮细胞中IC50为0.1pM。
靶点信息
| Microtubule (human endothelial cells) | | | | |
| 0.1 pM | | | | |
化学数据
| 目录号 | A10689 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 853.9 |
| Formula | C47H51NO14 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 33069-62-4 |
| Synonyms | Taxol |
| SMILES | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C |
溶解度
| In vitro (25°C) | DMSO | 152 mg/mL (178 mM) |
| Water | Insoluble |
| Ethanol | 16 mg/mL (18.73 mM) |
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+ddH2O | 5 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 11.71 mL | 58.55 mL | 117.11 mL |
| 0.5 mM | 2.34 mL | 11.71 mL | 23.42 mL |
| 1 mM | 1.17 mL | 5.86 mL | 11.71 mL |
| 5 mM | 0.23 mL | 1.17 mL | 2.34 mL |
*The above data is based on the productmolecular weight 853.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
