生物活性
PIK-90是一种合成的磷酸肌醇3激酶（PI3K）抑制剂，对于p110α，β，γ和δ亚型的IC50值（nM）为11、350、18和58，mTOR活性低。
靶点信息
| PI3Kα | PI3Kγ | PI3Kδ | PI3Kβ | |
| 11 nM | 18 nM | 58 nM | 350 nM | |
化学数据
| 目录号 | A10730 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 351.4 |
| Formula | C18H17N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 677338-12-4 |
| Synonyms | PIK90 |
| SMILES | COC1=C(C2=C(C=C1)C3=NCCN3C(=N2)NC(=O)C4=CN=CC=C4)OC |
溶解度
| In vitro (25°C) | DMSO | 0.27 mg/mL (0.76 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4 | 14 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 28.46 mL | 142.29 mL | 284.58 mL |
| 0.5 mM | 5.69 mL | 28.46 mL | 56.92 mL |
| 1 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
*The above data is based on the productmolecular weight 351.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
