生物活性
SGX-523是一种口服生物可利用的小分子，与c-Met蛋白或HGFR特异性结合，可防止HGF结合并破坏MET信号通路。
Targets
| Target | Value |
| c-Met | IC50: 4nM |
| B-Raf(V599E) | IC50: >7μM |
| C-Raf | IC50: >7μM |
| Abl | IC50: >7μM |
| p38α | IC50: >7μM |
| Abl1(Y253F) | IC50: >7μM |
化学数据
| 目录号 | A10839 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 359.4 |
| Formula | C18H13N7S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1022150-57-7 |
| Synonyms | SGX523 |
| SMILES | CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2 |
溶解度
| In vitro (25°C) | DMSO | Warmed: 3 mg/mL (8.34 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 0.5% methylcellulose+0.2% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 27.82 mL | 139.12 mL | 278.24 mL |
| 0.5 mM | 5.56 mL | 27.82 mL | 55.65 mL |
| 1 mM | 2.78 mL | 13.91 mL | 27.82 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
*The above data is based on the productmolecular weight 359.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
