SP600125

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SP600125

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

129-56-6

包装与价格：

包装	价格(元)
10mg	询价
50mg	询价
200mg	询价
10mM * 1mL in DMSO	询价

生物活性

SP600125是一种JNK抑制剂，对于JNK-1和JNK-2，IC50 = 40 nM，对于JNK-3，IC50 = 90 nM。

Targets

Target	Value
JNK1	IC50: 40nM
JNK2	IC50: 40nM
AuroraA	IC50: 60nM
TrkA	IC50: 70nM
JNK3	IC50: 90nM
FLT3	IC50: 90nM
MKK4	IC50: 0.4μM
MKK6	IC50: 1.0μM
PKB	IC50: 1.0μM
MKK3	IC50: 1.5μM
PKCα	IC50: 1.5μM
p56LCK	IC50: 4.3μM
MKK7	IC50: 5.1μM
MEKK1	IC50: >10μM
ERK2	IC50: >10μM
p38β	IC50: >10μM
PKA	IC50: >10μM
PKC	IC50: >10μM
PKCθ	IC50: >10μM
Chk1	IC50: >10μM
EGF	IC50: >10μM
IKK1	IC50: >10μM
IKK2	IC50: >10μM

化学数据

目录号	A10860
作用机制	Inhibitor (抑制剂)
M. Wt	220.2
Formula	C14H8N2O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	129-56-6
SMILES	C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O

溶解度

In vitro (25°C)	DMSO	43 mg/mL (195.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	1 mg/mL
<1 mg/ml means slightly soluble or insoluble. Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	45.41 mL	227.07 mL	454.13 mL
0.5 mM	9.08 mL	45.41 mL	90.83 mL
1 mM	4.54 mL	22.71 mL	45.41 mL
5 mM	0.91 mL	4.54 mL	9.08 mL

*The above data is based on the productmolecular weight 220.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.