生物活性
Vincristine sulfate是一种有丝分裂抑制剂。
靶点信息
| Microtubules (Cell-free assay) | | | | |
| 32 μM | | | | |
化学数据
| 目录号 | A10973 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 923.0 |
| Formula | C46H56N4O10.H2SO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 2068-78-2 |
| Synonyms | Leurocristine, VCR |
| SMILES | CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O |
溶解度
| In vitro (25°C) | DMSO | 86 mg/mL (93.16 mM) |
| Water | 52 mg/mL (56.33 mM) |
| Ethanol | Insoluble |
| In vivo | Saline | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 10.83 mL | 54.17 mL | 108.34 mL |
| 0.5 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 1 mM | 1.08 mL | 5.42 mL | 10.83 mL |
| 5 mM | 0.22 mL | 1.08 mL | 2.17 mL |
*The above data is based on the productmolecular weight 923.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
