生物活性
VX-765 (Belnacasan)是一种新型的Caspase-1抑制剂，是一种控制两种细胞因子IL-1b和IL-18生成的酶。
靶点信息
| Caspase-4 (Cell-free assay) | Caspase-1 (Cell-free assay) | | | |
| <0.6 nM(Ki) | 0.8 nM(Ki) | | | |
化学数据
| 目录号 | A10984 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 509.0 |
| Formula | C24H33ClN4O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 273404-37-8 |
| Synonyms | VX765 |
| SMILES | CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl |
溶解度
| In vitro (25°C) | DMSO | Warmed: 87 mg/mL (170.92 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 87 mg/mL (170.92 mM) |
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.65 mL | 98.23 mL | 196.46 mL |
| 0.5 mM | 3.93 mL | 19.65 mL | 39.29 mL |
| 1 mM | 1.96 mL | 9.82 mL | 19.65 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
*The above data is based on the productmolecular weight 509.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
