生物活性
NVP-AEW541是一种选择性的IGF-1R激酶抑制剂，可抑制IGF-1R的自磷酸化活性（IC50 = 0.086 uM）并阻止IGF-1介导的MCF-7细胞存活和增殖（IC50分别为0.16和1.64 uM）。
化学数据
| 目录号 | A11021 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 439.6 |
| Formula | C27H29N5O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 475489-16-8 |
| Synonyms | AEW541 |
| SMILES | C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6 |
溶解度
| In vitro (25°C) | DMSO | 77 mg/mL (175.18 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 19 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.75 mL | 113.74 mL | 227.48 mL |
| 0.5 mM | 4.55 mL | 22.75 mL | 45.5 mL |
| 1 mM | 2.27 mL | 11.37 mL | 22.75 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.55 mL |
*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
