生物活性
AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。
靶点信息
| EGFR (Cell-free assay) | HER2 (Cell-free assay) | PDGFR (Cell-free assay) | | |
| 3 nM | >100 μM | >100 μM | | |
化学数据
| 目录号 | A11022 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 315.8 |
| Formula | C16H14ClN3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 153436-53-4 |
| Synonyms | AG1478, AG 1478 |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC |
溶解度
| In vitro (25°C) | DMSO | 25 mg/mL (79.17 mM) |
| Water | Insoluble |
| Ethanol | 13 mg/mL (41.17 mM) |
| In vivo | 15% Captisol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 31.67 mL | 158.33 mL | 316.66 mL |
| 0.5 mM | 6.33 mL | 31.67 mL | 63.33 mL |
| 1 mM | 3.17 mL | 15.83 mL | 31.67 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
*The above data is based on the productmolecular weight 315.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
