生物活性
Pneumocandin B0是脂肽家族的主要类似物，该脂肽家族是从几个不同属的几个物种中分离出来的，特别是隐孢子虫，Glarea和Pezicula。Pneumocandin B0是一种有效的抗真菌药，可通过抑制易感真菌细胞壁必不可少的成分β-（1,3）-D-葡聚糖的合成来发挥作用。
化学数据
| 目录号 | A11113 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 1065.2 |
| Formula | C50H80N8O17 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 135575-42-7 |
| SMILES | O=C(N1[C@@]([H])([C@H](CC1)O)C(N[C@H](O)[C@H](O)C[C@H](NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)C(NC2[C@@H](C)O)=O)=O)[C@]([H])([C@@H](CC(N)=O)O)NC(C([C@@H]([C@@H](O)C3=CC=C(C=C3)O)O)NC([C@]4([H])C[C@H](CN4C2=O)O)=O)=O |
溶解度
| In vitro | DMSO | 92 mg/mL (86.36 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 9.39 mL | 46.94 mL | 93.88 mL |
| 0.5 mM | 1.88 mL | 9.39 mL | 18.78 mL |
| 1 mM | 0.94 mL | 4.69 mL | 9.39 mL |
| 5 mM | 0.19 mL | 0.94 mL | 1.88 mL |
*The above data is based on the productmolecular weight 1065.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
