生物活性
AST-1306是一种新型的苯胺-喹唑啉化合物，在无细胞和基于细胞的系统中均抑制野生型表皮生长因子受体（EGFR）和ErbB2以及EGFR抗性突变体的酶活性。
化学数据
| 目录号 | A11155 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 448.9 |
| Formula | C24H18ClFN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 897383-62-9 |
| Synonyms | AST1306 |
| SMILES | C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.28 mL | 111.38 mL | 222.77 mL |
| 0.5 mM | 4.46 mL | 22.28 mL | 44.55 mL |
| 1 mM | 2.23 mL | 11.14 mL | 22.28 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
*The above data is based on the productmolecular weight 448.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
