生物活性
JTT-705 (Dalcetrapib)是一种CETP抑制剂，抑制CETP是增加HDL-胆固醇并可能减少动脉粥样硬化的目标。
靶点信息
化学数据
| 目录号 | A11213 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 389.6 |
| Formula | C23H35NO2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 211513-37-0 |
| Synonyms | JTT705 |
| SMILES | CCC(CC)CC1(CCCCC1)C(=O)NC2=CC=CC=C2SC(=O)C(C)C |
溶解度
| In vitro (25°C) | DMSO | 66 mg/mL (169.41 mM) |
| Water | Insoluble |
| Ethanol | 66 mg/mL (169.41 mM) |
| In vivo | 0.5% methylcellulose | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.67 mL | 128.34 mL | 256.67 mL |
| 0.5 mM | 5.13 mL | 25.67 mL | 51.33 mL |
| 1 mM | 2.57 mL | 12.83 mL | 25.67 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.13 mL |
*The above data is based on the productmolecular weight 389.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
