生物活性
Linagliptin (BI-1356)是DPP-4抑制剂，是一种降解肠降血糖素激素胰高血糖素样肽1（GLP-1）和葡萄糖依赖性促胰岛素多肽（GIP）的酶。
靶点信息
化学数据
| 目录号 | A11224 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 472.5 |
| Formula | C25H28N8O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 668270-12-0 |
| Synonyms | BI-1356,Tradjenta,Trajenta |
| SMILES | CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C |
溶解度
| In vitro (25°C) | DMSO | 16 mg/mL (33.85 mM) |
| Water | Insoluble |
| Ethanol | 1 mg/mL (2.11 mM) |
| In vivo | 0.5% hydroxyethyl cellulose | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.16 mL | 105.82 mL | 211.64 mL |
| 0.5 mM | 4.23 mL | 21.16 mL | 42.33 mL |
| 1 mM | 2.12 mL | 10.58 mL | 21.16 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
*The above data is based on the productmolecular weight 472.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
