生物活性
Ambrisentan (BSF 208075)充当内皮素受体拮抗剂，对A型内皮素受体（ETA）具有选择性。
靶点信息
化学数据
| 目录号 | A11291 |
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 378.4 |
| Formula | C22H22N2O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 177036-94-1 |
| Synonyms | BSF 208075, |
| SMILES | CC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C |
溶解度
| In vitro | DMSO | 72 mg/mL (190.26 mM) |
| Water | Insoluble |
| Ethanol | 21 mg/mL (55.49 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.43 mL | 132.14 mL | 264.27 mL |
| 0.5 mM | 5.29 mL | 26.43 mL | 52.85 mL |
| 1 mM | 2.64 mL | 13.21 mL | 26.43 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.29 mL |
*The above data is based on the productmolecular weight 378.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
