生物活性
Bardoxolone甲基是口服的一流的合成三萜类化合物。它是Nrf2途径的诱导剂，可以抑制氧化应激和炎症。
靶点信息
化学数据
| 目录号 | A11323 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 505.7 |
| Formula | C32H43NO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 218600-53-4 |
| Synonyms | NSC 713200, CDDO-methyl ester |
| SMILES | C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC |
溶解度
| In vitro (25°C) | DMSO | 21 mg/mL (41.52 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 4%DMSO+30% PEG300+5% Tween+61%ddH2O | 2.3 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.77 mL | 98.87 mL | 197.75 mL |
| 0.5 mM | 3.95 mL | 19.77 mL | 39.55 mL |
| 1 mM | 1.98 mL | 9.89 mL | 19.77 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.95 mL |
*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
