生物活性
PA-824 (Pretomanid)是一种实验性抗结核药物，MIC为<1 μg/mL。
靶点信息
化学数据
| 目录号 | A11401 |
| M. Wt | 359.3 |
| Formula | C14H12F3N3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 187235-37-6 |
| Synonyms | PA824 |
| SMILES | C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F |
溶解度
| In vitro (25°C) | DMSO | 64 mg/mL (178.14 mM) |
| Water | Insoluble |
| Ethanol | 14 mg/mL (38.96 mM) |
| In vivo | 0.5% methylcellulose | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 27.83 mL | 139.16 mL | 278.32 mL |
| 0.5 mM | 5.57 mL | 27.83 mL | 55.66 mL |
| 1 mM | 2.78 mL | 13.92 mL | 27.83 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.57 mL |
*The above data is based on the productmolecular weight 359.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
