生物活性
MEK162 (ARRY-438162,Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。
靶点信息
化学数据
| 目录号 | A11493 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 440.0 |
| Formula | C17H15BrF2N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 606143-89-9 |
| Synonyms | ARRY-162, MEK-162, MEK 162 |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO |
溶解度
| In vitro (25°C) | DMSO | Warmed: 86 mg/mL (194.91 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 1% CMC+0.5% Tween-80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.73 mL | 113.64 mL | 227.27 mL |
| 0.5 mM | 4.55 mL | 22.73 mL | 45.45 mL |
| 1 mM | 2.27 mL | 11.36 mL | 22.73 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.55 mL |
*The above data is based on the productmolecular weight 440.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
