AZD5904是一种有效且不可逆的人髓过氧化物酶(MPO)抑制剂，其IC50值为140nM，在小鼠和大鼠中也具有相似的效力。
CAS：618913-30-7
分子式：C10H12N4O2S
分子量：252.29
纯度：98%
存储：Store at -20°C

Background:

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%[1].

[1]. Myeloperoxidase (MPO) inhibitor.